Emerging Biologic Strategies for Chronic Rhinosinusitis with Nasal Polyps

In collaboration with

ACKNOWLEDGEMENT OF COMMERCIAL SUPPORT
This activity is supported by an educational grant from Regeneron

TITLE: Emerging Biologic Strategies for Chronic Rhinosinusitis with Nasal Polyps

Release | Expiration: February XX, 2026 – February XX, 2027
 

STATEMENT OF NEED
Despite recent advances, several challenges continue to limit optimal use of biologics in CRSwNP. ENTs and allergists may underrecognize key clinical, inflammatory, and comorbid features that help identify candidates for biologic therapy and predict recurrence risk. Uncertainty persists around when to initiate biologics in relation to endoscopic sinus surgery, with limited guidance on whether they should be used before, after, or in place of surgery. The absence of U.S. specific position statements further contributes to variability in identifying which patients are appropriate candidates for biologics, determining the optimal timing of biologic initiation related to FESS, and selecting the best agent based on clinical and inflammatory profiles. In addition, poor communication between ENT and allergy teams often results in fragmented care, delayed decisions, and inconsistent treatment approaches
 

EDUCATIONAL OBJECTIVES

UTILIZE clinical and inflammatory features that guide biologic selection and signal recurrence risk in CRSwNP

DETERMINE how and when to incorporate biologics into CRSwNP management and sequencing treatment before, after, or in place of FESS

IMPLEMENT treatment strategies that incorporate biologics as add-on maintenance therapy for type 2 inflammation in CRSwNP, based on emerging guidance

STRENGTHEN cross-specialty collaboration between ENTs and allergists to ensure timely, coordinated care and appropriate integration of biologic therapies in CRSwNP
 

TARGET AUDIENCE
ENT’s and Allergy Clinicians (MDs and APPs)

FACULTY

	Cecelia Damask, DO, FAOCOHNS, FAAOA AdventHealth[CT1]  - Orlando ENT & Allergy Assistant Professor – Department of Otolaryngology University of Central Florida Orlando, FL
Disclosures	No relevant relationships

	Anju T. Peters, MD, MSCI Professor of Medicine Associate Chief of Clinical Research and Practice Innovation Division of Allergy and Immunology  Director, Center for Clinical Research Northwestern University Clinical and Translational Sciences Institute (NUCATS) Medical Director, Northwestern Medicine Clinical Research Unit Chicago, IL
Disclosures	No relevant relationships

TECHNICAL WRITER
Erika K. Lunz, PharmD
Disclosures
No relevant financial disclosures

PEER REVIEWER
Leonard Bacharier, MD FAAAAI
Disclosures
No relevant financial disclosures
 

ACCREDITED PROVIDER DISCLOSURE
None of the planners, reviewers, and AAAAI and RealCME staff for this educational activity have relevant financial relationship(s) with ineligible companies to disclose.
 

DISCLOSURE OF FINANCIAL RELATIONSHIPS POLICY
AAAAI adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of a CME/CE activity, including faculty, planners, reviewers, or others are required to disclose all financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest have been mitigated prior to the commencement of the activity.


ACCREDITED PROVIDER & ACCREDITATION STATEMENTS
This activity is accredited through AAAAI. 

CME: The American Academy of Allergy Asthma and Immunology (AAAAI) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CE: The American Academy of Allergy Asthma and Immunology (AAAAI) is a Provider approved by the California Board of Registered Nursing, Provider #10704.

CREDIT DESIGNATION STATEMENT
The AAAAI designates this activity for up to 0.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.


DISCLOSURE OF UNLABELED USE
This activity may or may not discuss investigational, unapproved, or off-label use of drugs. Participants are advised to consult prescribing information for any products discussed. The information provided in this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a clinician relative to diagnostic and treatment options for a specific patient's medical condition.

Disclaimer
The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of AAAAI and RealCME. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

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